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FoxO protein activation may be required for neuronal protection (Maiese, 2015), and a fine balance in FoxO activity may be required to target cognitive loss (Maiese, 2015)

289 Additionally, the size of the older adult population is expected to continue to increase relative to the population age 64 and youngera shift known as population agingdue to a projected decline in fertility, as well as to increased survival at older ages